The Textbook of Pharmaceutical Organic Chemistry-I serves as a fundamental resource for students pursuing pharmaceutical sciences. This book provides a systematic introduction to organic chemistry, emphasizing its applications in the pharmaceutical field. It begins with an in-depth discussion on the classification and nomenclature of organic compounds, covering both common and IUPAC naming systems. The concept of structural isomerism is also explored to help students understand molecular variations. The book extensively covers alkanes, alkenes, and conjugated dienes, explaining their stabilities, hybridization, and reaction mechanisms such as electrophilic and free radical addition reactions. The study of E1 and E2 elimination reactions, their kinetics, and Saytzeff’s orientation is also included. Furthermore, the book delves into alkyl halides, exploring SN1 and SN2 nucleophilic substitution reactions, their stereochemistry, and factors affecting their mechanisms.
In addition, the textbook provides a comprehensive study of alcohols, carbonyl compounds, and carboxylic acids, discussing their structures, qualitative tests, and pharmaceutical applications. Reactions such as aldol condensation, Cannizzaro reaction, and benzoin condensation are explained in detail, along with their importance in organic synthesis. The acidity of carboxylic acids and the effect of substituents on acidity are analyzed, with a focus on their pharmaceutical relevance. The book also covers amines and their basicity, including the impact of substituents on their properties. Special attention is given to pharmaceutical compounds such as amphetamine, ethanolamine, and ethylenediamine, explaining their chemical structures and therapeutic applications. Throughout the text, important industrial and medicinal compounds like benzyl benzoate, methyl salicylate, and acetylsalicylic acid are discussed, highlighting their roles in medicine and formulation sciences.
With clear explanations, reaction mechanisms, and real-world pharmaceutical applications, this textbook is a valuable guide for students. It not only builds a strong foundation in organic chemistry but also bridges the gap between theory and pharmaceutical practice, making it an essential resource for pharmacy students and professionals.