Pharmacology is a foundational discipline in medical and health sciences, offering critical insights into drug actions, therapeutic applications, and potential adverse effects. This book, Pharmacology-I, is a collaborative effort by seasoned professionals aimed at providing a comprehensive understanding of fundamental pharmacological principles and their clinical applications. It is meticulously designed to serve as an essential resource for students, researchers, and healthcare practitioners. Prof. Amol G. Jadhao, with his extensive expertise in clinical pharmacology, contributes a profound understanding of drug mechanisms and therapeutic strategies. His insights bridge the gap between theoretical concepts and clinical practice, enriching the reader’s comprehension of pharmacodynamics and pharmacokinetics. Prof. Madhuri Ashokrao Theng, renowned for her research in neuropharmacology, offers in-depth knowledge of central nervous system agents. Her contributions shed light on the pharmacological management of neurological disorders, emphasizing both established treatments and emerging therapies. Dr. Mohd Hasib Ahmed, an expert in cardiovascular pharmacology, provides detailed analyses of drugs affecting the cardiovascular system. His chapters encompass the latest advancements in antihypertensive, antiarrhythmic, and lipid-lowering agents, ensuring readers are well-versed in current therapeutic approaches. Prof. Meenakshi S. Nikam, with her specialization in toxicology, addresses the critical aspects of drug safety and adverse drug reactions. Her sections guide readers through the identification, management, and prevention of drug-induced toxicities, underscoring the importance of pharmacovigilance.