{"id":6133,"date":"2024-09-03T10:57:11","date_gmt":"2024-09-03T10:57:11","guid":{"rendered":"https:\/\/demopublication.edutechy.xyz\/?p=6133"},"modified":"2025-04-26T09:53:41","modified_gmt":"2025-04-26T09:53:41","slug":"chapter-17-pharmacogenomics-of-adverse-drug-reactions","status":"publish","type":"post","link":"https:\/\/sproutpublication.com\/index.php\/2024\/09\/03\/chapter-17-pharmacogenomics-of-adverse-drug-reactions\/","title":{"rendered":"Chapter 17: Pharmacogenomics of Adverse Drug Reactions"},"content":{"rendered":"<div class=\"fusion-fullwidth fullwidth-box fusion-builder-row-1 fusion-flex-container has-pattern-background has-mask-background nonhundred-percent-fullwidth non-hundred-percent-height-scrolling\" style=\"--awb-border-radius-top-left:0px;--awb-border-radius-top-right:0px;--awb-border-radius-bottom-right:0px;--awb-border-radius-bottom-left:0px;--awb-padding-right:20px;--awb-padding-left:20px;--awb-flex-wrap:wrap;\" ><div class=\"fusion-builder-row fusion-row fusion-flex-align-items-flex-start fusion-flex-content-wrap\" style=\"max-width:1248px;margin-left: calc(-4% \/ 2 );margin-right: calc(-4% \/ 2 );\"><div class=\"fusion-layout-column fusion_builder_column fusion-builder-column-0 fusion_builder_column_1_1 1_1 fusion-flex-column\" style=\"--awb-bg-size:cover;--awb-border-color:var(--awb-color3);--awb-border-style:solid;--awb-width-large:100%;--awb-margin-top-large:0px;--awb-spacing-right-large:1.92%;--awb-margin-bottom-large:20px;--awb-spacing-left-large:1.92%;--awb-width-medium:100%;--awb-order-medium:0;--awb-spacing-right-medium:1.92%;--awb-spacing-left-medium:1.92%;--awb-width-small:100%;--awb-order-small:0;--awb-spacing-right-small:1.92%;--awb-spacing-left-small:1.92%;\"><div class=\"fusion-column-wrapper fusion-column-has-shadow fusion-flex-justify-content-flex-start fusion-content-layout-column\"><div class=\"fusion-text fusion-text-1\" style=\"--awb-content-alignment:justify;--awb-font-size:16px;\"><p><strong>Author: <\/strong>Ms. Shikha Singh<br \/>\n<strong>Volume: <\/strong>01<br \/>\n<strong>First Online: <\/strong>31 August 2024<br \/>\n<strong>Pages: <\/strong> 260-271<br \/>\n<strong>DOI:<\/p>\n<\/div><div class=\"fusion-title title fusion-title-1 fusion-sep-none fusion-title-text fusion-title-size-two\" style=\"--awb-text-color:var(--awb-color8);--awb-font-size:20px;\"><h2 class=\"fusion-title-heading title-heading-left\" style=\"font-family:&quot;Roboto&quot;;font-style:normal;font-weight:700;margin:0;font-size:1em;\">Abstract<\/h2><\/div><div class=\"fusion-separator\" style=\"align-self: flex-start;margin-right:auto;margin-bottom:20px;width:100%;max-width:8%;\"><div class=\"fusion-separator-border sep-single sep-solid\" style=\"--awb-height:20px;--awb-amount:20px;--awb-sep-color:var(--awb-custom_color_1);border-color:var(--awb-custom_color_1);border-top-width:3px;\"><\/div><\/div><div class=\"fusion-text fusion-text-2\" style=\"--awb-content-alignment:justify;--awb-font-size:16px;--awb-text-font-family:&quot;Roboto&quot;;--awb-text-font-style:normal;--awb-text-font-weight:400;\"><p>Pharmacogenomics, the study of how genetic variations affect drug responses, plays a critical role in understanding and mitigating adverse drug reactions (ADRs). Genetic polymorphisms in drug-metabolizing enzymes, transporters, and receptors can influence drug efficacy and toxicity, leading to ADRs in certain individuals. By identifying genetic markers associated with these reactions, pharmacogenomics enables personalized medicine, allowing for tailored drug therapy that minimizes risks and enhances treatment outcomes. This field holds promise for predicting ADRs, particularly in populations with known genetic susceptibilities, thus improving drug safety and reducing the incidence of serious, sometimes life-threatening, adverse events. Advances in pharmacogenomics are also contributing to the development of safer drugs by guiding dose adjustments and alternative therapies based on a patient\u2019s genetic profile. As pharmacogenomic testing becomes more accessible, it is expected to become an integral part of routine clinical practice, offering the potential to transform drug safety and therapeutic efficacy on a global scale.<\/p>\n<p><strong>Keywords:<\/strong> Pharmacogenomics, Genetic Variations, Adverse Drug Reactions (ADRs), Drug-Metabolizing Enzymes, Drug Transporters, Drug Receptors<\/p>\n<\/div><\/div><\/div><\/div><\/div>\n","protected":false},"excerpt":{"rendered":"","protected":false},"author":1,"featured_media":0,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[144],"tags":[],"class_list":["post-6133","post","type-post","status-publish","format-standard","hentry","category-pharmacovigilance"],"_links":{"self":[{"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/posts\/6133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/comments?post=6133"}],"version-history":[{"count":3,"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/posts\/6133\/revisions"}],"predecessor-version":[{"id":7331,"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/posts\/6133\/revisions\/7331"}],"wp:attachment":[{"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/media?parent=6133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/categories?post=6133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/sproutpublication.com\/index.php\/wp-json\/wp\/v2\/tags?post=6133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}